I am honour’d by your Letter, desiring to know by what Means I am reliev’d in a Disorder with which you are unfortunately afflicted as well as my self. I have try’d all the noted Prescriptions for diminishing the Stone, without procuring any good Effect. But observing Temperance in Eating, avoiding wine and Cyder, and using daily the Dumb Bell, which exercises the upper Part of the Body without much moving the Parts in contact with the Stone, I think I have prevented its Increase. As the Roughness of the Stone lacerates a little the Neck of the Bladder I find that when the Urine happens to be sharp, I have much Pain in making Water and frequent Urgencies. For Relief under these Circumstances, I take going to Bed the Bigness of a Pigeon’s Egg of Jelly of Blackberries; the Receipt for making it is enclos’d. While I continue to do this every night I am generally easy the Day following, making Water pretty freely, and with long Intervals. I wish most earnestly that this simple Remedy may have the same happy Effect with you. Perhaps Currant Jelly, or the Jelly of Apples or Raspberries may be equally serviceable; for I suspect the Virtues of this Jelly may be principally in the boiled Sugar, which is in some degree candied by the Boiling of the Jelly. Wishing you for your own Sake much more Ease, and for the Sake of Mankind many more Years, I remain with the greatest Esteem and Respect, Dear Sir, Your affectionate and obedient Servant